Enos Steroid Analysis Lab

Enos lab Published works

A Novel Tissue-Specific Insight into Sex Steroid Fluctuations Throughout the Murine Estrous CycleSerum sex steroid levels fluctuate throughout the reproductive cycle. However, the degree to which sex steroid tissue content mimics circulating content is unknown. Understanding the flux and physiological quantity of tissue steroid content is ...

Skeletal Muscle Endogenous Estrogen Production Ameliorates the Metabolic Consequences of a High-Fat Diet in Male MiceThe role of skeletal muscle estrogen and its ability to mitigate the negative impact of a high-fat diet (HFD) on obesity-associated metabolic impairments is unknown. To address this, we developed a novel mouse model to determine the role of ...

Augmenting Skeletal Muscle Estrogen Does not Prevent or Rescue Obesity-linked Metabolic Impairments in Female MiceWe developed a novel mouse model with increased skeletal muscle estrogen content via inducible, skeletal-muscle–specific aromatase overexpression (SkM-Arom↑). We proposed to examine the effect that increased skeletal muscle estrogen both in ...

The deuterated glucose insulin tolerance test: a new tool to delineate insulin-stimulated glucose uptake from suppression of endogenous glucose production

Congenital adiponectin deficiency mitigates high-fat-diet-induced obesity in gonadally intact male and female, but not in ovariectomized miceEpidemiological literature indicates that women are less susceptible to type II diabetes (T2D) than males. The general consensus is that estrogen is protective, whereas its deficiency in post-menopause is associated with adiposity and impaired ...

Macrophage tumor necrosis factor-alpha deletion does not protect against obesity-associated metabolic dysfunctionThe pro-inflammatory cytokine, tumor necrosis factor-alpha (TNF-α), has been suggested to be a key factor in the induction of obesity-associated metabolic dysfunction. However, the role that macrophage-derived TNF-α has on regulating metabolic ...

How Stable is Your Vivarium’s Temperature? Fluctuations in Vivarium Temperature Significantly Impact Metabolism and Behavior Impeding Scientific ReproducibilityThe purpose of this investigation was to examine the variability in vivarium temperature and the impact that this has on metabolic and behavioral outcomes in mice. Daily vivarium temperature was monitored every day for a two-year period. Behavioral ...

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